Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24092039 | 0.73 | POLB (0.40) | AKR1C4AKR1C3AKR1C2AKR1C1SMN1; SMN2 | |
| SCHEMBL9593395 | 0.72 | NPC1 (0.45) | SMN1; SMN2RAB9AHPGDALDH1A1MEN1 | |
| SCHEMBL17887750 | 0.72 | POLB (0.40) | SMN1; SMN2RAB9AMEN1KMT2APOLB | |
| SCHEMBL19193199 | 0.72 | POLB (0.44) | SMN1; SMN2RAB9AHPGDALDH1A1MEN1 | |
| SCHEMBL1786515 | 0.72 | L3MBTL1 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1MEN1 | |
| SCHEMBL24258804 | 0.72 | AKR1C4 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| SCHEMBL6332424 | 0.71 | USP7 (0.46) | AKR1C4AKR1C3AKR1C2AKR1C1TP53 | |
| SCHEMBL6207925 | 0.71 | CA1 (0.35) | AKR1C4AKR1C3AKR1C2AKR1C1POLB | |
| SCHEMBL6328563 | 0.71 | LDHA (0.40) | AKR1C4AKR1C3AKR1C2AKR1C1TP53 | |
| SCHEMBL23578161 | 0.71 | POLB (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024059878-A9 | DRUGS TARGETING TELOMERASE REVERSE TRANSCRIPTASE (TERT) FOR TREATMENT OF CANCERS | BROWN UNIVERSITY (US) | 2024-07-04 | — | — | WO | disclosed |