Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007145 | 0.82 | HPGD (0.55) | MAPTHDAC6L3MBTL1CTDSP1HTT | |
| SCHEMBL3727867 | 0.77 | HDAC6 (0.45) | MAPTHDAC6L3MBTL1CTDSP1POLB | |
| SCHEMBL29431281 | 0.76 | HTT (0.53) | MAPTHDAC6L3MBTL1POLBHTT | |
| SCHEMBL1055281 | 0.74 | HDAC6 (0.56) | MAPTHDAC6L3MBTL1CTDSP1POLB | |
| SCHEMBL3502643 | 0.73 | L3MBTL1 (0.47) | HDAC6L3MBTL1CTDSP1POLBHTT | |
| SCHEMBL5947 | 0.73 | KDM4E (0.53) | MAPTHDAC6L3MBTL1POLBHTT | |
| SCHEMBL6112686 | 0.72 | KMT2A (0.41) | MAPTHDAC6L3MBTL1CTDSP1POLB | |
| Trifluoroacetic Acid SCHEMBL6976344 | 0.72 | AR (0.45) | MAPTHDAC6L3MBTL1POLBHTT | |
| SCHEMBL1608962 | 0.72 | HDAC6 (0.77) | MAPTHDAC6CTDSP1POLBHTT | |
| SCHEMBL15979923 | 0.72 | CTNNB1 (0.56) | MAPTCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554254-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | claimed |
| WO-2004035548-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-04-29 | — | — | WO | claimed |
| EP-1554254-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035548-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-04-29 | — | — | WO | disclosed |