SCHEMBL6208540

SCHEMBL6208540

Nc1ccccc1OCCCN1CCC(Cc2ccccc2)CC1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 1/20 0.70
SIGMAR1 Q99720 3/20 0.70
TMEM97 Q5BJF2 2/20 0.70
MEN1 O00255 4/20 0.65
KMT2A Q03164 4/20 0.65
HRH3 Q9Y5N1 2/20 0.64
SLC6A2 P23975 1/20 0.61
SLC6A4 P31645 1/20 0.61
CCR3 P51677 1/20 0.59
PRMT3 O60678 1/20 0.58
CARM1 Q86X55 1/20 0.58
PRMT6 Q96LA8 1/20 0.58
PRMT1 Q99873 1/20 0.58
PRMT8 Q9NR22 1/20 0.58
KDM4E B2RXH2 3/20 0.58
ALDH1A1 P00352 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58
GRIN2A Q12879 1/20 0.57
GRIN2B Q13224 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7398178 0.94 TMEM97 (0.69) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL7403447 0.85 TMEM97 (0.64) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL7404359 0.84 KDM4E (0.60) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL5888823 0.82 SIGMAR1 (1.00) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL7404358 0.81 SLC6A2 (0.74) DRD4SIGMAR1TMEM97HRH3SLC6A2
SCHEMBL13229777 0.80 SIGMAR1 (0.74) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL5199674 0.79 CCR3 (0.74) SIGMAR1TMEM97HRH3SLC6A2SLC6A4
SCHEMBL7399889 0.78 TMEM97 (0.69) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL7402687 0.78 KDM4E (0.72) DRD4SIGMAR1TMEM97MEN1KMT2A
SCHEMBL3102949 0.78 CARM1 (0.82) SIGMAR1TMEM97HRH3SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61115068-A None JP disclosed
EP-0869792-B1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 2005-03-09 EP disclosed
US-6124323-A ACTIVE DRUG TREATING STROKE, CEREBRAL ISCHEMIA, CENTRAL NERVOUS SYSTEM TRAUMA, HYPOGLYCEMIA, ANXIETY, CONVULSIONS, AMIOGLYCOSIDE ANTIBIOTICS-INDUCED HEARING LOSS, MIGRAINE HEADACHES, CHRONIC PAIN, GLAUCOMA, CMV RETINITIS, PSYCHOSIS WARNER-LAMBERT COMPANY (US) 2000-09-26 US disclosed
EP-0869792-A4 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 1999-09-22 EP disclosed
EP-0869792-A2 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-10-14 EP disclosed
WO-1997023216-A1 4-SUBSTITUTED PIPERIDINE ANALOGS AND THEIR USE AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1997-07-03 WO disclosed
JP-S61115068-A 4-BENZYLPIPERIDINYLPROPOXYANILINE DERIVATIVE HOKURIKU SEIYAKU CO LTD 1986-06-02 JP disclosed