Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | XIAP | P98170 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210989 | 0.89 | TSHR (0.36) | TSHRRORCDHODHRAB9ALMNA | |
| SCHEMBL3541027 | 0.83 | XIAP (0.40) | TSHRMAPK1XIAPSMN1; SMN2GAA | |
| SCHEMBL13314795 | 0.83 | XIAP (0.40) | TSHRMAPK1XIAPSMN1; SMN2GAA | |
| SCHEMBL6209697 | 0.81 | TSHR (0.34) | TSHRRORCDHODHXIAPSMN1; SMN2 | |
| SCHEMBL6210140 | 0.80 | TSHR (0.36) | TSHRRORCDHODHMEN1KMT2A | |
| SCHEMBL6211289 | 0.80 | MAPT (0.38) | SMN1; SMN2GAARAB9A | |
| Formic Acid SCHEMBL3537717 | 0.80 | XIAP (0.38) | MAPK1XIAPSMN1; SMN2GAARAB9A | |
| SCHEMBL6210046 | 0.79 | PARP1 (0.40) | TSHRRORCDHODHMEN1KMT2A | |
| SCHEMBL6208532 | 0.79 | RAB9A (0.40) | TSHRSMN1; SMN2RAB9ALMNA | |
| SCHEMBL6210127 | 0.77 | RAB9A (0.39) | MEN1KMT2ASMN1; SMN2GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608662-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-12-28 | — | — | EP | claimed |
| WO-2004083218-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-09-30 | — | — | WO | claimed |
| EP-1608662-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004083218-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-09-30 | — | — | WO | disclosed |