Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.48 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3225729 | 0.92 | MAPK14 (0.43) | MAPK14LDHANPC1RAB9AALDH1A1 | |
| SCHEMBL6207192 | 0.84 | MAPK14 (0.55) | MAPK14NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3225734 | 0.82 | MAPK14 (0.44) | MAPK14MAPK11 | |
| SCHEMBL6603680 | 0.81 | MCL1 (0.55) | MAPK14NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL11816232 | 0.81 | NPC1 (0.51) | NPC1RAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL19484711 | 0.78 | CSNK2A1 (0.43) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL5657829 | 0.76 | MAPK14 (0.57) | MAPK14NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL19472419 | 0.75 | CTSA (0.42) | BRD4 | |
| SCHEMBL10315084 | 0.75 | RAB9A (0.58) | NPC1RAB9AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28804822 | 0.75 | LDHA (0.57) | LDHAALDH1A1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499600-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093248-A1 | HETEROARYL SUBSTITUTED BIPHENYL DERIVATIVES AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-11-13 | — | — | WO | disclosed |