Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6212410 | 0.90 | POLB (0.35) | CTSKKMT2AMMP2MEN1 | |
| SCHEMBL6211805 | 0.89 | CTSK (0.35) | CTSKGAAALDH1A1KMT2A | |
| SCHEMBL4043889 | 0.85 | KDM4E (0.41) | KDM4ECYP2C9CYP2C19CTSKGAA | |
| SCHEMBL6267150 | 0.84 | CTSK (0.33) | CTSK | |
| SCHEMBL4042824 | 0.83 | KDM4E (0.40) | KDM4ECYP2C9CYP2C19CTSKGAA | |
| SCHEMBL4045822 | 0.82 | KDM4E (0.40) | KDM4ECYP2C9CYP2C19CTSKGAA | |
| SCHEMBL4041227 | 0.82 | CHRM1 (0.42) | KDM4ECYP2C9CYP2C19GAAALDH1A1 | |
| SCHEMBL6212648 | 0.81 | KDM4E (0.39) | KDM4ECYP2C9CYP2C19CTSKGAA | |
| SCHEMBL4043258 | 0.80 | KDM4E (0.39) | KDM4ECYP2C9CYP2C19CTSKGAA | |
| SCHEMBL4043087 | 0.80 | KDM4E (0.39) | KDM4ECYP2C9CYP2C19CTSKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | claimed |