Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 12/20 | 0.58 |
| ▸ | RPA1 | P27694 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6191291 | 0.84 | PTGS2 (0.42) | PTGS2PTGS1ABCB11ALDH1A1 | |
| SCHEMBL6191740 | 0.81 | PTGS2 (0.71) | PTGS2PTGS1TSHRNPSR1CYP1A2 | |
| SCHEMBL14504331 | 0.78 | PTGS2 (0.69) | PTGS2PTGS1RPA1ABCB11ALDH1A1 | |
| SCHEMBL8290876 | 0.78 | PTGS2 (0.73) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL5149058 | 0.78 | PTGS2 (0.65) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL7463985 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL8925551 | 0.76 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL14504808 | 0.75 | PTGS2 (0.62) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL677751 | 0.74 | PTGS2 (0.67) | PTGS2PTGS1ABCB11ALDH1A1TSHR | |
| SCHEMBL14504863 | 0.74 | PTGS2 (0.64) | PTGS2PTGS1RPA1ABCB11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567503-A1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050632-A1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-17 | — | — | WO | disclosed |