Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 9/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22529420 | 0.77 | CYP19A1 (0.46) | PYGLCYP19A1IDO1CNR1F2 | |
| SCHEMBL28394959 | 0.76 | CYP19A1 (0.54) | PYGLCYP19A1IDO1CNR1BCAT1 | |
| SCHEMBL28178529 | 0.76 | F2 (0.58) | PYGLCYP19A1IDO1CNR1F2 | |
| SCHEMBL22547173 | 0.76 | CNR1 (0.46) | PYGLCYP19A1IDO1CNR1BCAT1 | |
| SCHEMBL22529409 | 0.74 | CYP19A1 (0.43) | PYGLCYP19A1IDO1CNR1 | |
| SCHEMBL6341106 | 0.72 | PYGL (0.80) | PYGL | |
| SCHEMBL6345713 | 0.72 | PYGL (0.65) | PYGLBCAT1 | |
| SCHEMBL24076508 | 0.72 | CYP19A1 (0.47) | CYP19A1IDO1 | |
| SCHEMBL4270694 | 0.72 | SLC6A2 (0.46) | IDO1F2 | |
| SCHEMBL28692973 | 0.70 | LOXL2 (0.52) | PYGLIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569639-A2 | SUBSTITUTED DIHYDROPYRANO INDOLE-3,4-DIONE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | Wyeth (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052893-A2 | SUBSTITUTED DIHYDROPYRANO INDOLE-3,4-DIONE DERIVATIVES AND 3-OXOACETIC ACID SUBSTITUTED 2-HYDROXYMETHYLINDOLE DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) | WYETH (US) | 2004-06-24 | — | — | WO | disclosed |