Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043450 | 0.91 | MAPT (0.42) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL8347480 | 0.91 | MAPT (0.42) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL4046341 | 0.91 | MAPT (0.42) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL4040598 | 0.82 | CTSK (0.40) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL4039918 | 0.82 | CTSK (0.40) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL4224431 | 0.76 | MAPT (0.41) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL29272939 | 0.76 | MAPT (0.61) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL29272938 | 0.76 | MAPT (0.61) | MAPTNPSR1TDP1KDM4EMEN1 | |
| SCHEMBL4043831 | 0.76 | MAPT (0.36) | MAPTNPSR1TDP1MEN1KMT2A | |
| SCHEMBL30330579 | 0.74 | ABCB1 (0.43) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |