Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.40 |
| ▸ | CBX4 | O00257 | 3/20 | 0.40 |
| ▸ | CBX7 | O95931 | 3/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.40 |
| ▸ | CBX8 | Q9HC52 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CBX6 | O95503 | 1/20 | 0.39 |
| ▸ | CBX2 | Q14781 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039918 | 1.00 | CTSK (0.40) | CTSKCBX4CBX7CDYL2CBX8 | |
| SCHEMBL8347480 | 0.92 | MAPT (0.42) | CTSKMAPTMEN1KMT2APOLB | |
| SCHEMBL4046341 | 0.92 | MAPT (0.42) | CTSKMAPTMEN1KMT2APOLB | |
| SCHEMBL4043450 | 0.92 | MAPT (0.42) | CTSKMAPTMEN1KMT2APOLB | |
| SCHEMBL8350293 | 0.89 | CTSK (0.47) | CTSKCBX4CBX7CDYL2CBX8 | |
| SCHEMBL4040623 | 0.89 | CTSK (0.47) | CTSKCBX4CBX7CDYL2CBX8 | |
| SCHEMBL4040629 | 0.89 | CTSK (0.47) | CTSKCBX4CBX7CDYL2CBX8 | |
| SCHEMBL4043831 | 0.87 | MAPT (0.36) | CTSKMAPTMEN1KMT2APOLB | |
| SCHEMBL4224247 | 0.85 | CTSK (0.41) | CTSKCBX4CBX7CDYL2CBX8 | |
| SCHEMBL6209649 | 0.82 | MAPT (0.43) | CTSKMAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | disclosed |
| US-20060100431-A1 | Biologically active compounds | AMURA THERAPEUTICS LIMITED (GB) | 2006-05-11 | — | — | US | disclosed |
| EP-1546150-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | Amura Therapeutics Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004007501-A1 | BIOLOGICALLY ACTIVE COMPOUNDS | AMURA THERAPEUTICS LIMITED (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100431-A1 | Biologically active compounds | SOST, CTSK, CTSS | CTSK 2/4885CBX4 2841/4885CBX7 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.