SCHEMBL6209937

SCHEMBL6209937

NCC1(F)CCN(Cc2ccccc2)CC1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.57
HSD17B10 Q99714 1/20 0.57
SIGMAR1 Q99720 6/20 0.57
OPRL1 P41146 2/20 0.54
KDM1A O60341 1/20 0.53
TSHR P16473 3/20 0.53
ALDH1A1 P00352 2/20 0.53
CYP2C9 P11712 2/20 0.53
CYP2C19 P33261 2/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
HIF1A Q16665 1/20 0.53
POLB P06746 1/20 0.53
OPRM1 P35372 1/20 0.50
CYP2D6 P10635 2/20 0.49
CCR3 P51677 1/20 0.49
TP53 P04637 1/20 0.49
CYP1A2 P05177 1/20 0.49
MC4R P32245 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22254447 0.83 ALDH1A1 (0.53) SIGMAR1ALDH1A1MEN1KMT2APOLB
SCHEMBL1290790 0.83 OPRL1 (0.58) CYP3A4HSD17B10SIGMAR1OPRL1KDM1A
SCHEMBL3334062 0.82 SIGMAR1 (0.61) CYP3A4HSD17B10SIGMAR1OPRL1TSHR
SCHEMBL2918565 0.82 SIGMAR1 (0.65) CYP3A4HSD17B10SIGMAR1OPRL1TSHR
SCHEMBL20664058 0.82 KDM1A (0.57) KDM1ATSHRALDH1A1MEN1KMT2A
SCHEMBL1586461 0.81 CYP3A4 (0.59) CYP3A4HSD17B10SIGMAR1OPRL1TSHR
SCHEMBL25542044 0.80 KCNH2 (0.54) SIGMAR1OPRL1ALDH1A1MEN1KMT2A
SCHEMBL1314774 0.79 OPRL1 (0.63) CYP3A4HSD17B10SIGMAR1OPRL1TSHR
SCHEMBL14716284 0.79 CYP3A4 (0.57) CYP3A4HSD17B10SIGMAR1OPRL1TSHR
SCHEMBL4519530 0.79 CYP3A4 (0.57) CYP3A4HSD17B10SIGMAR1OPRL1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1390034-A4 N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS MERCK & CO INC (US) 2005-07-13 EP disclosed
EP-1390034-A1 N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS Merck & Co., Inc. (US) 2004-02-25 EP disclosed
EP-1379520-A1 N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS Merck & Co., Inc. (US) 2004-01-14 EP disclosed
WO-2002080928-A1 N-SUBSTITUTED NONARYL-HETEROCYCLO AMIDYL NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2002-10-17 WO disclosed
WO-2002068409-A1 N-SUBSTITUTED NONARYL-HETEROCYCLIC NMDA/NR2B ANTAGONISTS MERCK & CO., INC. (US) 2002-09-06 WO disclosed