Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208451 | 0.91 | LMNA (0.32) | TSHRRORCDHODHPARP1 | |
| SCHEMBL6209697 | 0.85 | TSHR (0.34) | TSHRRORCDHODH | |
| SCHEMBL6210989 | 0.83 | TSHR (0.36) | TSHRRORCDHODHPARP1 | |
| SCHEMBL6210046 | 0.82 | PARP1 (0.40) | TSHRRORCDHODHPARP1 | |
| SCHEMBL3543834 | 0.82 | XIAP (0.33) | TSHRPARP1 | |
| SCHEMBL13314801 | 0.82 | XIAP (0.33) | TSHRPARP1 | |
| SCHEMBL6210140 | 0.82 | TSHR (0.36) | TSHRRORCDHODHPARP1 | |
| SCHEMBL6209623 | 0.80 | MAPT (0.36) | RORCDHODH | |
| SCHEMBL6208826 | 0.77 | TSHR (0.34) | TSHRRORCDHODH | |
| SCHEMBL3536640 | 0.75 | MAPT (0.33) | TSHRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608662-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2005-12-28 | — | — | EP | claimed |
| WO-2004083218-A1 | GUANIDINE DERIVATIVES AND USE THEREOF AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2004-09-30 | — | — | WO | claimed |