Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.55 |
| ▸ | CTSS | P25774 | 9/20 | 0.55 |
| ▸ | CTSB | P07858 | 7/20 | 0.52 |
| ▸ | CTSL | P07711 | 8/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700384 | 1.00 | CTSK (0.55) | CTSKCTSSCTSBCTSL | |
| SCHEMBL6211886 | 0.89 | CTSK (0.67) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4701868 | 0.89 | CTSK (0.67) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4698421 | 0.88 | CTSK (0.51) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4699909 | 0.85 | CTSK (0.53) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4699985 | 0.84 | CTSK (0.52) | CTSKCTSSCTSBCTSL | |
| SCHEMBL6271092 | 0.84 | CTSK (0.52) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4701062 | 0.83 | CTSK (0.47) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4698876 | 0.82 | CTSS (0.58) | CTSKCTSSCTSBCTSL | |
| SCHEMBL4702083 | 0.81 | HRH3 (0.47) | CTSKCTSSCTSBCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |