Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.49 |
| ▸ | RPA1 | P27694 | 2/20 | 0.49 |
| ▸ | MARS1 | P56192 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | CCKAR | P32238 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148696 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5148713 | 0.83 | PTGS2 (0.53) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5148723 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5150623 | 0.80 | PTGS2 (0.53) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5152059 | 0.79 | PTGS2 (0.52) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7872946 | 0.79 | PTGS2 (0.62) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL6540577 | 0.78 | PTGS2 (0.51) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL5148744 | 0.77 | PTGS2 (0.50) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5147862 | 0.76 | MDM2 (0.59) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5150244 | 0.76 | PTGS2 (0.58) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567503-A1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004050632-A1 | PYRAZOLE DERIVATIVES USEFUL AS COX-I INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-17 | — | — | WO | disclosed |