Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7876680 | 0.88 | PTGS2 (0.51) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8421888 | 0.86 | PTGS2 (0.71) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8422275 | 0.86 | PTGS2 (0.82) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8423896 | 0.86 | PTGS2 (0.82) | PTGS2PTGS1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7468149 | 0.85 | PTGS2 (0.66) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL28740979 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL7465017 | 0.84 | CA1 (0.64) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL7874446 | 0.84 | PTGS2 (0.52) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL7867587 | 0.84 | PTGS2 (0.55) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL677827 | 0.84 | ALOX5 (0.65) | PTGS2PTGS1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316485-B1 | INHIBITS ACTIVITY OF CYCLOOXYGENASE-2; FOR THERAPY AND PROPHYLAXIS OF INFLAMMATION, THROMBOSIS, RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE; AS ANALGESIC | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| EP-1017678-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-12 | — | — | EP | disclosed |
| WO-1999015505-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |