Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.60 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8810240 | 0.98 | CCR5 (0.71) | CCR5ALDH1A1USP28USP25RAB9A | |
| Hydrochloric Acid SCHEMBL7809482 | 0.98 | CCR5 (0.71) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL6260325 | 0.88 | CCR5 (0.59) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL561347 | 0.85 | CCR5 (0.68) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL30353418 | 0.85 | CCR5 (0.68) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL15196646 | 0.85 | CCR5 (0.63) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL5699914 | 0.84 | CCR5 (1.00) | CCR5 | |
| SCHEMBL8406943 | 0.84 | HTR1A (0.65) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL16293746 | 0.84 | CCR5 (0.62) | CCR5ALDH1A1USP28USP25RAB9A | |
| SCHEMBL3724781 | 0.84 | CCR5 (0.66) | CCR5ALDH1A1USP28USP25RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216257-B1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | PFIZER PROD INC (US) | 2005-12-07 | — | — | EP | disclosed |
| US-6803457-B1 | ADENOSINE RECEPTORS; FOR REDUCTION OF TISSUE DAMAGE RESULTING FROM HYPOXIA/CARDIOVASCULAR DISORDERS IN MAMMALS/HUMANS | PFIZER, INC. | 2004-10-12 | — | — | US | disclosed |
| US-20040198693-A1 | Compounds for the treatment of ischemia | DENINNO MICHAEL P (US) | 2004-10-07 | — | — | US | disclosed |
| CN-1114598-C | Aromatic compounds and pharmaceutical compositions containing them | ZENECA LTD (GB) | 2003-07-16 | — | — | CN | disclosed |
| EP-1216257-A1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | Pfizer Products Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| CN-1085663-C | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2002-05-29 | — | — | CN | disclosed |
| WO-2001023399-A1 | COMPOUNDS FOR THE TREATMENT OF ISCHEMIA | PFIZER PRODUCTS INC. (US) | 2001-04-05 | — | — | WO | disclosed |
| CN-1286254-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2001-03-07 | — | — | CN | disclosed |
| CN-1193966-A | Aromatic compounds and pharmaceutical compositions containing them | ZENECA LTD (GB) | 1998-09-23 | — | — | CN | disclosed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | disclosed |
| WO-1997000864-A1 | AROMATIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ZENECA LIMITED (GB) | 1997-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198693-A1 | Compounds for the treatment of ischemia | TNNI3, ADRB3, FABP3 | CCR5 2406/4885ALDH1A1 1085/4885USP28 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.