Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216364 | 0.90 | ABCG2 (0.45) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL6216800 | 0.89 | IKBKB (0.43) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL6216687 | 0.89 | ALDH1A1 (0.50) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL4432076 | 0.87 | LHCGR (0.50) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL6217395 | 0.86 | LIMK1 (0.46) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL5025998 | 0.83 | BRAF (0.46) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL6216335 | 0.83 | EEF2K (0.38) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL6217543 | 0.81 | SMN1; SMN2 (0.44) | MAPTABCG2ALDH1A1HPGDKDM4E | |
| SCHEMBL6216809 | 0.81 | MAPT (0.43) | MAPTALDH1A1HPGDKDM4EGAA | |
| SCHEMBL6214611 | 0.80 | IKBKB (0.45) | MAPTALDH1A1KDM4ECHRM4LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | claimed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | claimed |
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |