Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218958 | 0.92 | ACHE (0.55) | ACHERPS6KA2 | |
| SCHEMBL5783192 | 0.88 | ACHE (0.38) | ACHERPS6KA2NR1I2UGCGKDM4E | |
| SCHEMBL5784229 | 0.88 | ACHE (0.38) | ACHERPS6KA2NR1I2UGCGKDM4E | |
| SCHEMBL6220595 | 0.87 | ACHE (0.39) | ACHEKDM4EALDH1A1KMT2A | |
| SCHEMBL5784447 | 0.85 | ACHE (0.41) | ACHERPS6KA2NR1I2UGCGKDM4E | |
| SCHEMBL6220121 | 0.85 | ACHE (0.41) | ACHERPS6KA2NR1I2UGCGKDM4E | |
| SCHEMBL6218216 | 0.84 | ACHE (0.41) | ACHEALDH1A1 | |
| SCHEMBL6217132 | 0.82 | ACHE (0.57) | ACHERPS6KA2CHRM3 | |
| SCHEMBL5783534 | 0.82 | HDAC1 (0.40) | ACHERPS6KA2KDM4EALDH1A1MAPT | |
| SCHEMBL5781219 | 0.81 | ACHE (0.39) | ACHERPS6KA2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414817-B1 | substituted isoindoles and the use thereof | BAYER HEALTHCARE AG (DE) | 2005-04-06 | — | — | EP | disclosed |