Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL449747 | 0.78 | HTR7 (0.55) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL1551501 | 0.73 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL4582219 | 0.71 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL1554549 | 0.71 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL1553141 | 0.70 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL449750 | 0.70 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL22736780 | 0.69 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL447864 | 0.69 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL451427 | 0.69 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 | |
| SCHEMBL450438 | 0.69 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2KDM4EMAPTTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521746-A1 | QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS | X-Ceptor Therapeutics, Inc. (US) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003076418-A1 | QUINAZOLINONE MODULATORS OF NUCLEAR RECEPTORS | X-CEPTOR THERAPEUTICS, INC. (US) | 2003-09-18 | — | — | WO | disclosed |