Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.75 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.75 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20784504 | 0.84 | ADORA2A (1.00) | ADORA2AADORA2B | |
| SCHEMBL6858372 | 0.84 | ADORA2A (1.00) | ADORA2AADORA2BADORA1 | |
| SCHEMBL2561122 | 0.82 | ADORA2A (1.00) | ADORA2AADORA2BADORA1 | |
| SCHEMBL6859749 | 0.81 | ADORA2A (0.77) | ADORA2AADORA2BADORA1 | |
| SCHEMBL6213678 | 0.81 | ADORA2A (1.00) | ADORA2AADORA2BADORA1 | |
| SCHEMBL6852763 | 0.81 | ADORA2A (0.77) | ADORA2AADORA2BADORA1 | |
| SCHEMBL6215001 | 0.80 | ADORA2A (0.81) | ADORA2AADORA2BADORA1 | |
| SCHEMBL20784762 | 0.79 | ADORA2B (1.00) | ADORA2AADORA2B | |
| SCHEMBL3705263 | 0.79 | ADORA2A (0.49) | ADORA2AADORA2BADORA1 | |
| SCHEMBL6858352 | 0.79 | ADORA2A (0.73) | ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192164-B1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2005-08-17 | — | — | EP | claimed |
| EP-1192164-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-04-03 | — | — | EP | claimed |
| WO-2001002409-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-01-11 | — | — | WO | claimed |
| EP-1192164-B1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RES LTD (GB) | 2005-08-17 | — | — | EP | disclosed |
| US-6787541-B1 | MOVEMENT DISORDERS, PARKINSON'S DISEASE | VERNALIS RESEARCH LIMITED (GB) | 2004-09-07 | — | — | US | disclosed |
| EP-1192164-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001002409-A1 | THIENO- AND FUROPYRIMIDINE DERIVATIVES AS A2A-RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-01-11 | — | — | WO | disclosed |