Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.56 |
| ▸ | PTGFR | P43088 | 1/20 | 0.56 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.56 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.56 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.47 |
| ▸ | SOX18 | P35713 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214765 | 1.00 | TBXA2R (0.56) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL30513113 | 0.85 | GPR52 (0.57) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL6790462 | 0.85 | CYP1A2 (0.45) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL27426512 | 0.85 | PTGER3 (0.41) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL27622370 | 0.82 | PTGER3 (0.65) | PTGER4PTGER3PTGER2PTGDRCYP1A2 | |
| SCHEMBL16289222 | 0.81 | CYP1A2 (0.60) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL14349796 | 0.81 | KMT2A (0.45) | TBXA2RPTGER4PTGFRPTGER3PTGER2 | |
| SCHEMBL30345495 | 0.80 | MAOB (0.44) | PTGER4PTGER2 | |
| SCHEMBL1233515 | 0.79 | MAOB (0.61) | PTGER4PTGER3PTGER2GPR52 | |
| SCHEMBL2555173 | 0.79 | MAOB (0.61) | PTGER4PTGER3PTGER2GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256583-B1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-10 | — | — | EP | disclosed |
| EP-1256583-A1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-11-13 | — | — | EP | disclosed |