Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 15/20 | 0.51 |
| ▸ | HTR2A | P28223 | 15/20 | 0.51 |
| ▸ | DRD3 | P35462 | 15/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567706 | 0.84 | KCNA3 (0.54) | DRD2HTR2ADRD3 | |
| SCHEMBL6214213 | 0.83 | DRD2 (0.50) | DRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL5568960 | 0.82 | NPC1 (0.55) | MAOBDRD2HTR2ADRD3 | |
| SCHEMBL5564015 | 0.82 | DRD2 (0.44) | MAOBDRD2HTR2ADRD3ADRA2A | |
| SCHEMBL5563913 | 0.82 | TSHR (0.57) | MAOBDRD2HTR2ADRD3 | |
| SCHEMBL6216523 | 0.81 | MAOB (0.48) | MAOBDRD2HTR2ADRD3 | |
| SCHEMBL3936968 | 0.80 | DRD4 (0.63) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL6217037 | 0.79 | MAOB (0.58) | MAOBDRD2HTR2ADRD3 | |
| SCHEMBL5564087 | 0.79 | DRD2 (0.50) | DRD2HTR2ADRD3SIGMAR1DRD4 | |
| SCHEMBL6642667 | 0.78 | SIGMAR1 (0.44) | MAOBDRD2HTR2ADRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1122254-B1 | 4-Sulfonamide piperidine derivatives, method for their preparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2005-04-27 | — | — | EP | disclosed |
| EP-1122254-A2 | 4-Sulfonamide piperidine derivatives, method for their preparation and phamaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-08-08 | — | — | EP | disclosed |