Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNA2 | P51530 | 1/20 | 0.61 |
| ▸ | CASP6 | P55212 | 1/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1277854 | 0.84 | DNA2 (0.83) | DNA2CASP6CTDSP1CLK1DYRK1A | |
| SCHEMBL3066032 | 0.81 | DNA2 (0.66) | DNA2CASP6CTDSP1CLK1DYRK1A | |
| SCHEMBL571879 | 0.79 | DNA2 (0.63) | DNA2CASP6CTDSP1CLK1DYRK1A | |
| SCHEMBL5897373 | 0.77 | CLEC4M (0.57) | DNA2CASP6CTDSP1FBP1ALDH1A1 | |
| SCHEMBL19220845 | 0.77 | DNA2 (0.72) | DNA2CASP6CTDSP1GUSBFBP1 | |
| SCHEMBL4334739 | 0.76 | DNA2 (1.00) | DNA2CASP6CTDSP1CLK1DYRK1A | |
| SCHEMBL6537720 | 0.75 | DNA2 (0.78) | DNA2CASP6CTDSP1CLK1DYRK1A | |
| SCHEMBL19220852 | 0.75 | DNA2 (0.71) | DNA2CASP6CTDSP1GUSBMEN1 | |
| SCHEMBL7539226 | 0.74 | CTSD (0.75) | CTSDALDH1A1L3MBTL1KDM4E | |
| SCHEMBL962966 | 0.74 | CTSD (1.00) | CTSDALDH1A1TDP1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222182-B1 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS | AVENTIS PHARMA INC (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1212269-B1 | METHODS FOR PREPARING N- (ALIPHATIC OR AROMATIC)CARBONYL)]-2-AMINOACETAMIDE COMPOUNDS AND FOR CYCLIZING SUCH COMPOUNDS | AVENTIS PHARMA INC (US) | 2004-10-27 | — | — | EP | disclosed |
| US-6599918-B2 | Inhibit Factor Xa Factor IIa (thrombin) | AVENTIS PHARMACEUTICALS INC. | 2003-07-29 | — | — | US | disclosed |
| US-20020193410-A1 | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans | AVENTIS PHARMACEUTICALS INC. | 2002-12-19 | — | — | US | disclosed |
| US-6492553-B1 | A METHOD FOR PREPARING A N-((ALIPHATIC OR AROMATIC)CARBONYL) )-2-AMINOACETAMIDE COMPOUND, AND FOR PREPARING A CYCLIZED COMPOUND THEREFROM, AS WELL AS NOVEL RESIN BOUND INTERMEDIATE COMPOUNDS THAT ARE USEFUL FOR PREPARING SUCH COMPOUNDS. | AVENTIS PHARAMACEUTICALS INC. | 2002-12-10 | — | — | US | disclosed |
| EP-1222182-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS | Aventis Pharmaceuticals Inc. (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-1212269-A1 | METHODS FOR PREPARING N- (ALIPHATIC OR AROMATIC)CARBONYL)]-2-AMINOACETAMIDE COMPOUNDS AND FOR CYCLIZING SUCH COMPOUNDS | Aventis Pharmaceuticals Products Inc. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014358-A2 | SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) DIHYDROBENZOFURANS AND BENOZOPYRANS | AVENTIS PHARMACEUTICALS INC. (DE) | 2001-03-01 | — | — | WO | disclosed |
| WO-2001010799-A1 | METHODS FOR PREPARING N-[(ALIPHATIC OR AROMATIC)CARBONYL)]-2-AMINOACETAMIDE COMPOUNDS AND FOR CYCLIZING SUCH COMPOUNDS | AVENTIS PHARMACEUTICAL PRODUCTS INC. (US) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193410-A1 | Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans | F2, TFPI, F3 | DNA2 2277/4885CASP6 1162/4885CTDSP1 1275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.