Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | DHODH | Q02127 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218802 | 0.94 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6216763 | 0.87 | KDM4E (0.61) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6214865 | 0.85 | LHCGR (0.60) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6217584 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6217895 | 0.84 | ALDH1A1 (0.50) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6215057 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6216798 | 0.84 | LHCGR (0.52) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6216192 | 0.84 | ALDH1A1 (0.62) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6428634 | 0.83 | MAPT (0.59) | ALDH1A1KDM4EMAPTGAAMAPK1 | |
| SCHEMBL6215667 | 0.83 | KDM4E (0.56) | ALDH1A1KDM4EMAPTGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |
| US-6569863-B1 | Luteinizing hormone (LH) agonists for controlling fertility | AKZO NOBEL NV (NL) | 2003-05-27 | — | — | US | disclosed |