Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Mevalonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | HMGCR | P04035 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MVD | P53602 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mevalonic Acid SCHEMBL29575532 | 1.00 | HMGCR (0.56) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL27658948 | 1.00 | HMGCR (0.56) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL27597534 | 1.00 | HMGCR (0.56) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL28177475 | 0.96 | HMGCR (0.52) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL120276 | 0.91 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL120275 | 0.91 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL8854071 | 0.91 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL18376074 | 0.91 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL29654223 | 0.89 | HMGCR (0.64) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL31294828 | 0.89 | HMGCR (0.64) | HMGCRCHRM1TBXA2RADRA1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380989-B1 | METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A | ASAHI KASEI PHARMA CORP (JP) | 2015-07-01 | — | — | EP | claimed |
| US-20120040387-A1 | METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-02-16 | — | — | US | claimed |
| EP-2380989-A1 | METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A | Asahi Kasei Pharma Corporation (JP) | 2011-10-26 | — | — | EP | claimed |
| CN-120167011-A | Biosynthesis of isoprenoids | 新加坡科技研究局 | 2025-06-17 | — | — | CN | disclosed |
| CN-118922528-A | Biosynthesis of apocarotenoids by controlling oxidative stress | 新加坡科技研究局 | 2024-11-08 | — | — | CN | disclosed |
| CN-118813433-A | Genetically engineered bacterium for producing beta-carotene and preparation method and application thereof | 苏州一兮生物技术有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-114848656-B | Inhibitors of mevalonate pathway as efficient vaccine adjuvants | 清华大学 | 2024-09-27 | — | — | CN | disclosed |
| CN-117778218-A | Recombinant yarrowia lipolytica capable of producing abscisic acid in high yield as well as construction method and application thereof | 南京工业大学 | 2024-03-29 | — | — | CN | disclosed |
| CN-109715815-B | Mevalonate diphosphate decarboxylase variant and process for producing olefin compound using the same | 国立研究开发法人理化学研究所 | 2022-11-29 | — | — | CN | disclosed |
| US-10975411-B2 | Method and reagent for measuring mevalonic acid, 3-hydroxymethylglutaryl coenzyme A, and coenzyme A | ASAHI KASEI PHARMA CORPORATION (JP) | 2021-04-13 | — | — | US | disclosed |
| US-20170037443-A1 | METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A | ASAHI KASEI PHARMA CORPORATION (JP) | 2017-02-09 | — | — | US | disclosed |
| US-9458491-B2 | Method and reagent for measuring mevalonic acid, 3-hydroxymethylglutaryl coenzyme A, and coenzyme A | ASAHI KASEI PHARMA CORPORATION (JP) | 2016-10-04 | — | — | US | disclosed |
| EP-2380989-B1 | METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A | ASAHI KASEI PHARMA CORP (JP) | 2015-07-01 | — | — | EP | disclosed |
| US-20130281493-A1 | Method for Treating Cancer Harboring a p53 Mutation | THE TRUSTEES OF THE UNIVERSITY OF COLUMBIA IN THE CITY OF NEW YORK (US) | 2013-10-24 | — | — | US | disclosed |
| EP-2625294-A2 | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION | Columbia University (US) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012048303-A2 | METHOD FOR TREATING CANCER HARBORING A p53 MUTATION | COLUMBIA UNIVERSITY (US) | 2012-04-12 | — | — | WO | disclosed |
| US-20120040387-A1 | METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A | ASAHI KASEI PHARMA CORPORATION (JP) | 2012-02-16 | — | — | US | disclosed |
| EP-2380989-A1 | METHOD AND REAGENT FOR DETERMINING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL-COENZYME A AND COENZYME A | Asahi Kasei Pharma Corporation (JP) | 2011-10-26 | — | — | EP | disclosed |
| CN-1297532-A | Method for identifying a chemically active ingredient inhibiting the 1-deoxy-D-xylulose 5-phosphate biosynthetic pathway and said active ingredient | JOMAA HASSAN (DE) | 2001-05-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040387-A1 | METHOD AND REAGENT FOR MEASURING MEVALONIC ACID, 3-HYDROXYMETHYLGLUTARYL COENZYME A, AND COENZYME A | HMGCR, COASY, CYP11A1 | ADRA1A 1617/4885HMGCR 1/4885CHRM1 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.