Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LHCGR | P22888 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.45 |
| ▸ | FSHR | P23945 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
| ▸ | AKT2 | P31751 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6217802 | 0.80 | LHCGR (0.58) | LHCGRTSHRFSHRBRAF | |
| SCHEMBL6216753 | 0.78 | LHCGR (0.55) | LHCGRTSHRFSHR | |
| SCHEMBL6215311 | 0.75 | LHCGR (0.61) | LHCGRTSHRFSHRBRAF | |
| SCHEMBL6216455 | 0.74 | LHCGR (0.59) | LHCGRTSHRFSHR | |
| SCHEMBL6220425 | 0.74 | LHCGR (0.55) | LHCGRTSHRFSHR | |
| SCHEMBL6217652 | 0.73 | LIMK1 (0.58) | LHCGRTSHRBRAF | |
| SCHEMBL6216808 | 0.73 | LHCGR (0.64) | LHCGRTSHRFSHR | |
| SCHEMBL6215184 | 0.72 | LHCGR (0.51) | LHCGRTSHRFSHR | |
| SCHEMBL6217408 | 0.72 | LHCGR (0.60) | LHCGRTSHR | |
| SCHEMBL6217253 | 0.71 | LHCGR (0.51) | LHCGRTSHRFSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171443-B1 | BICYCLIC HETEROAROMATIC COMPOUNDS USEFUL AS LH AGONISTS | AKZO NOBEL NV (NL) | 2005-07-13 | — | — | EP | disclosed |
| US-6841553-B2 | Bicyclic heteroaromatic compounds useful as LH agonists | AKZO NOBEL N.V. (NL) | 2005-01-11 | — | — | US | disclosed |
| US-6569863-B1 | Luteinizing hormone (LH) agonists for controlling fertility | AKZO NOBEL NV (NL) | 2003-05-27 | — | — | US | disclosed |