Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.34 |
| ▸ | HTR2C | P28335 | 6/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 6/20 | 0.32 |
| ▸ | HTR2B | P41595 | 5/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216964 | 0.90 | MAPK1 (0.34) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6218592 | 0.85 | SLC6A2 (0.39) | SLC6A2SLC6A4HTR2CMAPK1KMT2A | |
| SCHEMBL6216628 | 0.84 | MAPK1 (0.36) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL4926099 | 0.82 | MAPK1 (0.36) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6674372 | 0.79 | AHR (0.34) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6669223 | 0.79 | AHR (0.34) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6215819 | 0.78 | HTR2C (0.41) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6216300 | 0.77 | HTR2C (0.41) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL6217518 | 0.76 | MAPK1 (0.40) | AHRSLC6A2SLC6A4HTR2CMAPK1 | |
| SCHEMBL905993 | 0.76 | MAPK1 (0.40) | AHRSLC6A2SLC6A4HTR2CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414819-B1 | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES | PHARMACIA & UPJOHN CO LLC (US) | 2005-10-12 | — | — | EP | claimed |
| US-6849640-B2 | Therapeutic 1H-pyrido [4,3-b] indoles | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-01 | — | — | US | claimed |
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | claimed |
| EP-1414819-B1 | THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES | PHARMACIA & UPJOHN CO LLC (US) | 2005-10-12 | — | — | EP | disclosed |
| US-6849640-B2 | Therapeutic 1H-pyrido [4,3-b] indoles | PHARMACIA & UPJOHN COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | PHARMACIA & UPJOHN COMPANY | 2003-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060464-A1 | Therapeutic 1H-pyrido [ 4, 3-b ] indoles | HTR3B, HTR4, HTR3C | AHR 263/4885SLC6A2 55/4885SLC6A4 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.