Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13857947 | 0.81 | HDAC3 (0.46) | SLC9A1ALDH1A1S1PR4S1PR5SLC22A12 | |
| SCHEMBL10209453 | 0.77 | KMT2A (0.43) | SLC9A1ALDH1A1POLBL3MBTL1S1PR4 | |
| SCHEMBL717886 | 0.77 | CYP2A6 (0.53) | SLC9A1ALDH1A1POLBL3MBTL1RIPK1 | |
| SCHEMBL2096283 | 0.77 | SLC9A1 (0.41) | SLC9A1ALDH1A1POLBL3MBTL1RIPK1 | |
| SCHEMBL12741 | 0.73 | CYP2A6 (0.58) | — | |
| SCHEMBL12095346 | 0.73 | CYP2A6 (0.53) | SLC9A1ALDH1A1POLBL3MBTL1RIPK1 | |
| SCHEMBL14035721 | 0.69 | ADORA2A (0.36) | SLC9A1ALDH1A1POLBL3MBTL1S1PR4 | |
| SCHEMBL16795794 | 0.68 | NPC1 (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2403651 | 0.67 | SLC9A1 (0.45) | SLC9A1ALDH1A1POLBL3MBTL1RIPK1 | |
| SCHEMBL716537 | 0.67 | TRPM8 (0.39) | SLC9A1ALDH1A1POLBL3MBTL1S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |