Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057186 | 0.77 | ADORA2B (0.63) | ADORA2B | |
| SCHEMBL6217412 | 0.70 | ADORA2B (0.46) | TP53ALDH1A1GAALMNASMN1; SMN2 | |
| SCHEMBL6217049 | 0.68 | ADORA2B (0.52) | POLBALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL6218229 | 0.63 | ADORA2B (0.53) | ADORA2B | |
| SCHEMBL15381493 | 0.62 | CYP3A4 (0.66) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL6214870 | 0.61 | ADORA2B (0.57) | ALDH1A1SMN1; SMN2ADORA2B | |
| SCHEMBL6215790 | 0.60 | ADORA2B (0.57) | LMNAHTTTSHRADORA2B | |
| SCHEMBL28017364 | 0.59 | USP2 (0.52) | TP53POLBALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27911916 | 0.59 | GBA1 (0.58) | LMNAMAPTHTTSMN1; SMN2KMT2A | |
| SCHEMBL31652127 | 0.59 | CYP1A2 (0.52) | ALDH1A1LMNAMAPTKMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492793-A1 | NEW-4-(PYRROLOPYRIMIDIN-6-YL)BENZENESULPHONAMIDE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082873-A1 | NEW-4-(PYRROLOPYRIMIDIN-6-YL)BENZENESULPHONAMIDE DERIVATIVES | ALMIRALL PRODESFARMA, S.A. (ES) | 2003-10-09 | — | — | WO | disclosed |