SCHEMBL6218752

SCHEMBL6218752

CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCc1c[c]ccc1N2

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR4 P46093 4/20 0.78
PPARG P37231 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6220831 0.88 GPR4 (0.83) GPR4PPARG
SCHEMBL6220826 0.87 GPR4 (0.82) GPR4PPARG
SCHEMBL4365180 0.87 GPR4 (1.00) GPR4PPARG
SCHEMBL6046509 0.87 GPR4 (0.82) GPR4PPARG
SCHEMBL6046475 0.87 GPR4 (0.82) GPR4PPARG
SCHEMBL6046479 0.87 GPR4 (0.78) GPR4PPARG
SCHEMBL6046465 0.86 GPR4 (0.76) GPR4PPARG
SCHEMBL6046481 0.86 GPR4 (0.79) GPR4PPARG
SCHEMBL6046526 0.86 GPR4 (1.00) GPR4PPARG
SCHEMBL6046508 0.86 GPR4 (0.82) GPR4PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1547616-A1 PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH KYOWA HAKKO KOGYO CO., LTD. (JP) 2005-06-29 EP disclosed
EP-1537879-A1 PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA KYOWA HAKKO KOGYO CO., LTD. (JP) 2005-06-08 EP disclosed