Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6220831 | 0.91 | GPR4 (0.83) | GPR4PPARG | |
| SCHEMBL6220826 | 0.90 | GPR4 (0.82) | GPR4PPARG | |
| SCHEMBL4365180 | 0.90 | GPR4 (1.00) | GPR4PPARG | |
| SCHEMBL6046509 | 0.90 | GPR4 (0.82) | GPR4PPARG | |
| SCHEMBL6046464 | 0.89 | GPR4 (0.76) | GPR4 | |
| SCHEMBL6046508 | 0.88 | GPR4 (0.82) | GPR4PPARG | |
| SCHEMBL6046481 | 0.88 | GPR4 (0.79) | GPR4PPARG | |
| SCHEMBL6046526 | 0.88 | GPR4 (1.00) | GPR4PPARG | |
| SCHEMBL6046468 | 0.88 | GPR4 (0.98) | GPR4PPARG | |
| SCHEMBL6046489 | 0.88 | GPR4 (0.73) | GPR4PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242151-B2 | Tricyclic compounds | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-08-14 | — | — | US | disclosed |
| US-8242151-B2 | Tricyclic compounds | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-08-14 | — | — | US | disclosed |
| US-20090176760-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-07-09 | — | — | US | disclosed |
| US-20090176760-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-07-09 | — | — | US | disclosed |
| EP-1988091-A1 | TRICYCLIC COMPOUNDS | Kyowa Hakko Kogyo Co., Ltd (JP) | 2008-11-05 | — | — | EP | disclosed |
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-10-26 | — | — | US | disclosed |
| EP-1547616-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ITCH | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| EP-1537879-A1 | PREVENTIVE AND/OR THERAPEUTIC DRUGS FOR ASTHMA | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060239999-A1 | Preventive and/or therapeutic drugs for asthma | GPR4, HRH4, GPR3 | GPR4 1/4885PPARG 435/4885 |
| US-20090176760-A1 | TRICYCLIC COMPOUNDS | PPARG, PPARD, PPARA | GPR4 72/4885PPARG 1/4885 |
| US-20060252679-A1 | Preventive and/or trerapeutic drgs for itch | GPR4, TRPV1, TRPV4 | GPR4 1/4885PPARG 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.