Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057120 | 0.86 | LMNA (0.55) | MAPTKDM4ERAB9ALMNANPC1 | |
| Hydrochloric Acid SCHEMBL9052847 | 0.84 | LMNA (0.54) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL6222546 | 0.80 | RAB9A (0.60) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL7859708 | 0.80 | RAB9A (0.55) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL2487083 | 0.80 | RAB9A (0.56) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL4316935 | 0.80 | RAB9A (0.55) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL7830964 | 0.80 | MAPT (0.50) | MAPTKDM4ERAB9ALMNANPC1 | |
| Hydrochloric Acid SCHEMBL7707460 | 0.79 | RAB9A (0.55) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL7831504 | 0.79 | MAPT (0.54) | MAPTKDM4ERAB9ALMNANPC1 | |
| SCHEMBL7831937 | 0.79 | RAB9A (0.54) | MAPTKDM4ERAB9ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445731-B1 | Azabicyclo and azacyclo oxime and amine cholinergic agents and pharmaceutically acceptable salts thereof | WARNER LAMBERT CO (US) | 1996-01-10 | — | — | EP | claimed |
| US-5482938-A | Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment | WARNER-LAMBERT COMPANY (US) | 1996-01-09 | — | — | US | claimed |
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |