Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.71 |
| ▸ | ACHE | P22303 | 2/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27773273 | 0.85 | HTR2A (0.69) | HTR2AACHECCR3SIGMAR1RECQL | |
| SCHEMBL8551473 | 0.83 | HTR2A (0.68) | HTR2AACHECCR3SIGMAR1RECQL | |
| Hydrochloric Acid SCHEMBL8552504 | 0.82 | HTR2A (0.66) | HTR2AACHECCR3SIGMAR1RECQL | |
| SCHEMBL28160815 | 0.80 | CCR3 (0.63) | HTR2AACHECCR3SIGMAR1RECQL | |
| SCHEMBL4257757 | 0.80 | ACHE (0.69) | HTR2AACHECCR3SIGMAR1DRD2 | |
| SCHEMBL6335815 | 0.79 | HTT (0.67) | HTR2AACHESIGMAR1RECQLSMN1; SMN2 | |
| SCHEMBL4924760 | 0.79 | HTR2A (0.61) | HTR2AACHECCR3SIGMAR1RECQL | |
| SCHEMBL10800201 | 0.78 | HTR2A (0.83) | HTR2AACHECCR3RECQLSMN1; SMN2 | |
| SCHEMBL8315434 | 0.77 | ACHE (0.71) | HTR2AACHECCR3SIGMAR1DRD2 | |
| SCHEMBL22433373 | 0.77 | SMN1; SMN2 (0.46) | HTR2ASMN1; SMN2HTR2CKCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501827-A2 | PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACID AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2004091549-A2 | PROCESS FOR MAKING ALPHA-SUBSTITUTED HYDROXAMIC ACIDS | PHARMACIA CORPORATION (US) | 2004-10-28 | — | — | WO | disclosed |
| WO-2003091247-A2 | PIPERIDINYL-AND PIPERAZINYL-SULFONYLMETHYL HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2003-11-06 | — | — | WO | disclosed |