Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.37 |
| ▸ | CPA1 | P15085 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL6212785 | 1.00 | KDM4E (0.48) | KDM4ETAAR1HRH3HCAR2TBXAS1 | |
| Cadaverine Tartrate SCHEMBL6218257 | 1.00 | KDM4E (0.48) | KDM4ETAAR1HRH3HCAR2TBXAS1 | |
| Pyridine SCHEMBL28133711 | 0.87 | HRH3 (0.50) | TAAR1HRH3 | |
| Pyridine SCHEMBL28192678 | 0.85 | HRH3 (0.49) | TAAR1HRH3 | |
| Niacin SCHEMBL28160298 | 0.77 | GAA (0.57) | KDM4ETAAR1HRH3HCAR2TBXAS1 | |
| SCHEMBL1108477 | 0.76 | TAAR1 (0.50) | TAAR1HRH3HCAR2 | |
| SCHEMBL20117842 | 0.75 | HRH3 (0.55) | TAAR1HRH3 | |
| Pyridine SCHEMBL28265736 | 0.75 | HRH3 (0.38) | TAAR1HRH3 | |
| Hydrochloric Acid SCHEMBL27287864 | 0.75 | TAAR1 (0.48) | KDM4ETAAR1HRH3 | |
| Pyridine SCHEMBL28090960 | 0.72 | ALDH1A1 (0.46) | KDM4EKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077979-B1 | METHOD FOR PRODUCING (S,S)-BENZYL-2,8-DIAZABICYCLO 4.3.0]NONANE | BAYER HEALTHCARE AG (DE) | 2005-07-06 | — | — | EP | disclosed |
| EP-1077979-A1 | METHOD FOR PRODUCING (S,S)-BENZYL-2,8-DIAZABICYCLO 4.3.0]NONANE | BAYER AG (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058532-A1 | METHOD FOR PRODUCING (S,S)-BENZYL-2,8-DIAZABICYCLO[4.3.0]NONANE | BAYER AKTIENGESELLSCHAFT (DE) | 1999-11-18 | — | — | WO | disclosed |