Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218371 | 0.91 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1MAPK1NPC1 | |
| SCHEMBL6220580 | 0.91 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1MAPK1NPC1 | |
| SCHEMBL5467362 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPK1HPGD | |
| SCHEMBL5474220 | 0.78 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1MAPK1HPGD | |
| SCHEMBL2860755 | 0.77 | MEN1 (0.62) | MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6219644 | 0.73 | KMT2A (0.46) | MEN1KMT2AALDH1A1MAPK1NPC1 | |
| SCHEMBL2867611 | 0.71 | MEN1 (0.53) | MEN1KMT2AALDH1A1 | |
| SCHEMBL6220387 | 0.70 | KCNA5 (0.39) | MEN1KMT2AALDH1A1MAPK1HPGD | |
| SCHEMBL5460016 | 0.70 | ALDH1A1 (0.39) | MEN1KMT2AALDH1A1MAPK1HPGD | |
| SCHEMBL6219637 | 0.69 | KMT2A (0.46) | MEN1KMT2AALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507504-A1 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003063797-A2 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-08-07 | — | — | WO | disclosed |