Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6218368 | 0.89 | MEN1 (0.43) | KMT2AMEN1ALDH1A1MAPK1LMNA | |
| SCHEMBL6219644 | 0.75 | KMT2A (0.46) | KMT2AMEN1ALDH1A1MAPK1LMNA | |
| SCHEMBL6219641 | 0.69 | MEN1 (0.47) | KMT2AMEN1ALDH1A1MAPK1LMNA | |
| SCHEMBL6220384 | 0.68 | MEN1 (0.39) | KMT2AMEN1ALDH1A1MAPK1NPC1 | |
| SCHEMBL11239859 | 0.67 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL3455875 | 0.67 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL3455507 | 0.66 | MEN1 (0.62) | KMT2AMEN1ALDH1A1MAPK1NPC1 | |
| SCHEMBL13761422 | 0.66 | TP53 (0.68) | KMT2AMEN1ALDH1A1TP53NPC1 | |
| SCHEMBL17137884 | 0.66 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1MAPK1LMNA | |
| SCHEMBL16464174 | 0.65 | P2RX7 (0.55) | KMT2AMEN1ALDH1A1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507504-A1 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | Bristol-Myers Squibb Company (US) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003063797-A2 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-08-07 | — | — | WO | disclosed |