Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17847865 | 0.98 | KMT2A (0.54) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2314704 | 0.85 | KMT2A (0.53) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL8120684 | 0.82 | KMT2A (0.54) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL19036932 | 0.80 | KMT2A (0.38) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL19031341 | 0.79 | CYP2D6 (0.39) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1716730 | 0.79 | CYP2D6 (0.39) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11606548 | 0.79 | KMT2A (0.51) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL13394254 | 0.78 | KMT2A (0.70) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL19036931 | 0.77 | CYP2D6 (0.40) | KMT2ASMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL1723901 | 0.77 | CYP2D6 (0.40) | KMT2ASMN1; SMN2POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537105-A2 | SYNTHESIS OF INDOLIZINES | Synta Pharmaceuticals Corporation (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040152897-A1 | Synthesis of indolizines | SYNTA PHARMACEUTICALS CORP. (US) | 2004-08-05 | — | — | US | disclosed |
| WO-2004024727-A2 | SYNTHESIS OF INDOLIZINES | SYNTA PHARMACEUTICALS CORP. (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152897-A1 | Synthesis of indolizines | INMT, IDO1, IDO2 | KMT2A 783/4885SMN1; SMN2 3615/4885POLB 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.