Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221564 | 1.00 | MEN1 (0.46) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL6218975 | 0.89 | NPC1 (0.50) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL4539373 | 0.80 | ALDH1A1 (0.64) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL4366238 | 0.80 | ALDH1A1 (0.64) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL4366041 | 0.76 | NPC1 (0.47) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL4373587 | 0.76 | NPC1 (0.47) | MEN1KMT2ASMN1; SMN2LMNAMAPT | |
| SCHEMBL6219672 | 0.72 | F9 (0.40) | KDM4ECASR | |
| SCHEMBL11128200 | 0.71 | TSHR (0.56) | MEN1KMT2ASMN1; SMN2POLBRAB9A | |
| SCHEMBL4365512 | 0.71 | NPC1 (0.56) | MEN1KMT2ASMN1; SMN2HTTLMNA | |
| SCHEMBL4364669 | 0.71 | NPC1 (0.56) | MEN1KMT2ASMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562895-A1 | SUBSTITUTED ARYL ACYLTHIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | Achillion Pharmaceuticals, Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| WO-2004046095-A1 | SUBSTITUTED ARYL THIOUREAS AND RELATED COMPOUNDS; INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2004-06-03 | — | — | WO | claimed |