SCHEMBL11128200

SCHEMBL11128200

COC(=O)Nc1cccc(OC(C)c2ccccc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.56
ALDH1A1 P00352 3/20 0.55
FAAH O00519 1/20 0.55
CYP3A4 P08684 1/20 0.55
MAPK1 P28482 1/20 0.55
HPGD P15428 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
RORC P51449 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
NPC1 O15118 2/20 0.50
RAB9A P51151 1/20 0.50
NLRP3 Q96P20 1/20 0.50
KDM4E B2RXH2 1/20 0.50
CASR P41180 1/20 0.50
NPY5R Q15761 1/20 0.49
CYP1A2 P05177 1/20 0.49
ATM Q13315 1/20 0.48
POLB P06746 1/20 0.47
USP2 O75604 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27539123 0.83 TSHR (0.60) TSHRALDH1A1MEN1KMT2ANPC1
SCHEMBL2098030 0.83 ALDH1A1 (0.66) TSHRALDH1A1FAAHCYP3A4MAPK1
SCHEMBL3424219 0.82 ALDH1A1 (0.49) TSHRALDH1A1SMN1; SMN2RORCMEN1
SCHEMBL3428346 0.82 ALDH1A1 (0.49) TSHRALDH1A1SMN1; SMN2RORCMEN1
SCHEMBL11382382 0.79 ALDH1A1 (0.78) TSHRALDH1A1FAAHCYP3A4MAPK1
SCHEMBL2091354 0.79 FADS1 (0.56) ALDH1A1FAAHCYP3A4MAPK1HPGD
SCHEMBL2096261 0.78 TP53 (0.68) TSHRALDH1A1FAAHCYP3A4MAPK1
SCHEMBL716889 0.76 MAPK1 (0.62) ALDH1A1FAAHCYP3A4MAPK1HPGD
SCHEMBL1013517 0.75 CYP1A2 (0.65) ALDH1A1FAAHCYP3A4MAPK1SMN1; SMN2
SCHEMBL28765727 0.75 SMN1; SMN2 (0.49) ALDH1A1HPGDSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0041613-B1 DERIVATIVES OF ARALKYLANILINE AND HERBICIDES CONTAINING THESE COMPOUNDS BASF Aktiengesellschaft (DE) 1984-02-01 EP disclosed