Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | AGER | Q15109 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923120 | 0.81 | DNM1 (0.59) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL18002366 | 0.81 | DNM1 (0.51) | TRPA1DNM1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13995586 | 0.80 | TSHR (0.50) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL16264696 | 0.80 | TSHR (0.56) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4530213 | 0.80 | DNM1 (0.54) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL4530889 | 0.80 | DNM1 (0.54) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL18890757 | 0.79 | CARM1 (0.48) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL9700093 | 0.78 | DNM1 (0.55) | DNM1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL9762885 | 0.78 | DNM1 (0.46) | TRPA1DNM1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10624580 | 0.77 | DNM1 (0.54) | DNM1SMN1; SMN2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587782-A1 | 3-ARYLOXY/THIO-3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPINEPHRINE REUPTAKE | Eli Lilly and Company (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004043904-A1 | 3-ARYLOXY/THIO-3-SUBSTITUTED PROPANAMINES AND THEIR USE IN INHIBITING SEROTONIN AND NOREPHINEPHRINE REUPTAKE | ELI LILLY AND COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |