Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13556581 | 0.87 | CYP3A4 (0.58) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL6222140 | 0.86 | CYP3A4 (0.44) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL4269741 | 0.83 | CYP3A4 (0.47) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL9826356 | 0.82 | CYP3A4 (0.40) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL10987515 | 0.81 | CYP3A4 (0.36) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL2278837 | 0.81 | PDE2A (0.39) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL31135862 | 0.81 | CES2 (0.46) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL10905501 | 0.81 | CES2 (0.46) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL4517179 | 0.81 | GABRA1 (0.44) | CYP3A4TRPA1ALDH1A1HPGDTDP1 | |
| SCHEMBL162605 | 0.80 | PDE2A (0.41) | CYP3A4ALDH1A1HPGDTDP1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011392-A2 | PROLINE UREA CCR1 ANTAGONISTS FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR INFLAMMATION | LIGAND PHARMACUETICALS INCORPORATED (US) | 2008-01-24 | — | — | WO | disclosed |
| EP-1511385-B1 | INSECTICIDAL AMIDES WITH NITROGEN-CONTAINING BENZO-FUSED BICYCLIC RING SYSTEMS | DU PONT (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050147633-A1 | Insecticidal amides with nitrogen-containing benzo-Fused bicyclic ring systems | E. I. DU PONT DE NEMOURS AND COMPANY | 2005-07-07 | — | — | US | disclosed |
| EP-1511385-A1 | INSECTICIDAL AMIDES WITH NITROGEN-CONTAINING BENZO-FUSED BICYCLIC RING SYSTEMS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003103398-A1 | INSECTICIDAL AMIDES WITH NITROGEN-CONTAINING BENZO-FUSED BICYCLIC RING SYSTEMS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050147633-A1 | Insecticidal amides with nitrogen-containing benzo-Fused bicyclic ring systems | NIT2, CHRM1, BRS3 | CYP3A4 356/4885TRPA1 120/4885ALDH1A1 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.