Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSPO | P30536 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278775 | 0.93 | ALDH1A1 (0.64) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL13687190 | 0.88 | LMNA (0.62) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL11429803 | 0.87 | LMNA (0.57) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL10816551 | 0.87 | ALDH1A1 (0.57) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL18154278 | 0.85 | ALDH1A1 (0.56) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL15762363 | 0.84 | LMNA (0.66) | ALDH1A1LMNAHSD17B10TRPM8TSHR | |
| SCHEMBL13434152 | 0.84 | ALDH1A1 (0.58) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL11022276 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL7600830 | 0.83 | MEN1 (0.54) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 | |
| SCHEMBL11766317 | 0.83 | ALDH1A1 (0.45) | ALDH1A1LMNAHSD17B10POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575947-A1 | 2-OXOPYRIDIN-3-YL THIA(DI)AZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | Amgen Inc. (US) | 2005-09-21 | — | — | EP | claimed |
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | claimed |
| EP-1575947-A1 | 2-OXOPYRIDIN-3-YL THIA(DI)AZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | Amgen Inc. (US) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004060890-A1 | 2-OXOPYRIDIN-3-YL THIA (DI) AZOLE DERIVATES FOR USE IN THE TREATMENT OF CELL PROLIFERATION AND APOPTOSIS RELATED DISEASES | AMGEN INC. (US) | 2004-07-22 | — | — | WO | disclosed |
| CN-1300730-A | Process for preparing aminoformate compounds with CO2 instead of severely toxic optical gas | SHANGHAI INST ORGANIC CHEM (CN) | 2001-06-27 | — | — | CN | disclosed |
| CN-1224001-A | Process for preparation of carbonates and polycarbonates | MONSANTO CO (US) | 1999-07-28 | — | — | CN | disclosed |