Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 10/20 | 0.42 |
| ▸ | SRC | P12931 | 6/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 6/20 | 0.40 |
| ▸ | HCK | P08631 | 3/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 3/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823902 | 0.88 | ABL1 (0.54) | ABL1SRCTGFBR1PTK6HCK | |
| SCHEMBL6220508 | 0.81 | SRC (0.51) | CFTRABL1SRCTGFBR1PTK6 | |
| SCHEMBL7138358 | 0.77 | ABL1 (0.52) | ABL1SRCPTK6HCKFYN | |
| SCHEMBL6692919 | 0.73 | SRC (0.45) | ABL1SRCPTK6HCKFYN | |
| SCHEMBL5801455 | 0.73 | SRC (0.59) | ABL1SRCTGFBR1PTK6HCK | |
| SCHEMBL5802027 | 0.73 | SRC (0.54) | ABL1SRCTGFBR1PTK6HCK | |
| SCHEMBL4823038 | 0.71 | KDR (0.70) | ABL1SRCTGFBR1HCKFGFR1 | |
| SCHEMBL5822930 | 0.69 | SRC (0.51) | ABL1SRCHCKPIK3CDEGFR | |
| SCHEMBL519566 | 0.69 | KDM4E (0.44) | CFTRBACE1 | |
| SCHEMBL5822010 | 0.68 | SRC (0.48) | ABL1SRCTGFBR1HCKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385524-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2006-02-01 | — | — | EP | disclosed |
| EP-1385524-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | Abbott GmbH & Co. KG (DE) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002080926-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-17 | — | — | WO | disclosed |