Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222458 | 0.84 | VDR (0.40) | VDRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6221701 | 0.83 | SRC (0.43) | VDRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6221700 | 0.83 | SRC (0.43) | VDRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL27979862 | 0.83 | KMT2A (0.55) | MEN1KMT2AALDH1A1MAPTUSP2 | |
| SCHEMBL6222457 | 0.82 | MEN1 (0.38) | VDRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL27979723 | 0.82 | CYP19A1 (0.57) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6221893 | 0.81 | CYP1A2 (0.44) | MEN1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6221159 | 0.81 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL6222401 | 0.81 | MAPT (0.38) | VDRMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL6223026 | 0.81 | MAPT (0.38) | VDRMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137413-B1 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMA (US) | 2005-02-02 | — | — | EP | disclosed |
| US-6469021-B1 | ANTAGONISTS OF THE INTESTINAL HORMONE GLUCAGONS-LIKE PEPTIDE 1 (GLP-1) HAVE A 9H-B-CARBOLINE CENTRAL MOTIF, FOR REGULATING THE SECRETION OF INSULIN IN DIABETIC PATIENTS | AGOURON PHARMACEUTICALS, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-1137413-A4 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMA (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1137413-A2 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | EP | disclosed |
| WO-2000033839-A1 | NON-PEPTIDE ANTAGONISTS OF GLP-1 RECEPTOR AND METHODS OF USE | AGOURON PHARMACEUTICALS, INC. (US) | 2000-06-15 | — | — | WO | disclosed |