Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131117 | 1.00 | UGT2B7 (0.55) | UGT2B7MMP9SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12871846 | 0.94 | UGT2B7 (0.61) | UGT2B7MMP9SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23742756 | 0.86 | UGT2B7 (0.57) | UGT2B7MMP9SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15979349 | 0.86 | UGT2B7 (0.57) | UGT2B7MMP9SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6220348 | 0.83 | CASR (0.55) | UGT2B7MMP9SLC6A2CYP1A2SIGMAR1 | |
| SCHEMBL283979 | 0.81 | SIGMAR1 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL1200137 | 0.81 | SIGMAR1 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL30763462 | 0.81 | SIGMAR1 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8437895 | 0.81 | SIGMAR1 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL3749295 | 0.81 | SIGMAR1 (0.61) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553078-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2005-07-13 | — | — | EP | disclosed |
| EP-1275635-A1 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1203761-A2 | Calcium receptor-active compounds | NPS PHARMACEUTICALS, INC. (US) | 2002-05-08 | — | — | EP | disclosed |
| US-6211244-B1 | AROMATIC AMINES FOR COMPLEXING CALCIUM | NPS PHARMACEUTICALS, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1996012697-A9 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | NPS PHARMA INC (US) | 2000-08-24 | — | — | WO | disclosed |
| EP-0787122-A2 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996012697-A2 | CALCIUM RECEPTOR-ACTIVE COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 1996-05-02 | — | — | WO | disclosed |