Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7648128 | 0.79 | KDM4E (0.33) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7479445 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL27924016 | 0.72 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL7654900 | 0.71 | PARP1 (0.33) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL4735612 | 0.71 | ALDH1A1 (0.54) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL7773123 | 0.70 | KDM4E (0.55) | PARP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL4024234 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL17513978 | 0.70 | ATM (0.41) | PARP1ALDH1A1HPGDMAPTTSHR | |
| SCHEMBL17513891 | 0.70 | CD38 (0.36) | PARP1KDM4EALDH1A1MAPTTSHR | |
| SCHEMBL17514014 | 0.69 | ATM (0.53) | ALDH1A1HPGDMAPTTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194425-B1 | SUBSTITUTED BENZIMIDAZOLE | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| US-6358978-B1 | FOR THERAPY AND PROPHYLAXIS OF RHEUMATOID ARTHRITIS (IN THE CASE OF INFLAMMATION), OSTEOARTHRITIS, ASTHMA, CARDIAC INFARCT, ALZHEIMER'S DISEASE, OR ATHEROSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-03-19 | — | — | US | disclosed |