Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 15/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | APOB | P04114 | 5/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792699 | 0.85 | MTTP (0.58) | MTTPALDH1A1APOBNTRK1KDM4E | |
| SCHEMBL6261203 | 0.83 | MTTP (0.62) | MTTPALDH1A1APOBNTRK1 | |
| SCHEMBL6800233 | 0.82 | MTTP (0.54) | MTTPALDH1A1 | |
| SCHEMBL7605566 | 0.81 | MTTP (0.62) | MTTPAPOB | |
| SCHEMBL6789828 | 0.81 | PTGS1 (0.58) | MTTPALDH1A1APOBGAA | |
| SCHEMBL3726100 | 0.80 | MTTP (0.52) | MTTPALDH1A1APOBGAA | |
| SCHEMBL18083709 | 0.78 | CNR2 (0.49) | ALDH1A1KDM4EGAA | |
| SCHEMBL3730934 | 0.78 | PPARG (0.55) | MTTPAPOBNTRK1GAA | |
| SCHEMBL3726011 | 0.78 | MTTP (0.52) | MTTPALDH1A1APOB | |
| SCHEMBL3726013 | 0.78 | MTTP (0.50) | MTTPALDH1A1APOBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581499-A1 | MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056775-A1 | MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITORS | PFIZER PRODUCTS INC. (US) | 2004-07-08 | — | — | WO | disclosed |
| US-20040132779-A1 | Microsomal Triglyceride transfer protein inhibitor | PFIZER INC | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132779-A1 | Microsomal Triglyceride transfer protein inhibitor | MTTP, CETP, APOB | MTTP 1/4885ALDH1A1 1625/4885APOB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.