Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6221158 | 0.91 | ADORA1 (0.49) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6221526 | 0.88 | ALDH1A1 (0.51) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6221477 | 0.85 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6224664 | 0.84 | KDM4E (0.43) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6220800 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6792756 | 0.83 | ADORA1 (0.47) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6223507 | 0.83 | ADORA1 (0.47) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6222368 | 0.82 | KDM4E (0.47) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6224356 | 0.82 | ADORA1 (0.47) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL6222515 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4EHSD17B10CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1225173-B1 | NAPHTHYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2005-09-28 | — | — | EP | disclosed |
| US-6740662-B1 | HAVING 2-OXO-1,2-DIHYDRO- FUNCTIONALITY; PHOSPHODIESTERASE INHIBITORS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2004-05-25 | — | — | US | disclosed |
| EP-1225173-A1 | NAPHTHYRIDINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-07-24 | — | — | EP | disclosed |