Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 3/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222810 | 0.92 | PDE3B (0.46) | PDE3BPDE3AP2RY12ITGB1ITGA5 | |
| SCHEMBL6280034 | 0.90 | PDE3B (0.44) | PDE3BPDE3AP2RY12ITGB1ITGA5 | |
| SCHEMBL6289067 | 0.83 | PDE3B (0.43) | PDE3BPDE3AP2RY12ITGB1ITGA5 | |
| SCHEMBL6221415 | 0.81 | NPC1 (0.42) | ITGB1ITGA5ITGA4MAPTPPARG | |
| SCHEMBL7010549 | 0.74 | PPARG (0.51) | PPARG | |
| SCHEMBL6221979 | 0.74 | ITGB1 (0.53) | ITGB1ITGA5ITGA4MAPTPPARG | |
| SCHEMBL6281586 | 0.73 | MAPT (0.39) | ITGB1ITGA5MAPTITGB3ITGA2B | |
| SCHEMBL6222076 | 0.73 | LDHA (0.42) | PDE3BPDE3AP2RY12ITGB1ITGA5 | |
| SCHEMBL6221855 | 0.73 | NPC1 (0.42) | ITGB1ITGA5MAPTPPARGITGB3 | |
| SCHEMBL7018527 | 0.71 | PPARG (0.43) | PPARGITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282621-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | AVENTIS PHARMA SA (FR) | 2005-09-07 | — | — | EP | disclosed |
| EP-1282621-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | Aventis Pharma S.A. (FR) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085729-A1 | NOVEL VITRONECTIN RECEPTOR ANTAGONISTS | AVENTIS PHARMA S.A. (FR) | 2001-11-15 | — | — | WO | disclosed |