Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28090234 | 0.83 | HDAC1 (0.49) | HDAC1HDAC8PIK3CAHDAC3HDAC2 | |
| SCHEMBL4305804 | 0.82 | PIK3CA (0.56) | HDAC1HDAC8PIK3CACNR2MAPK8 | |
| SCHEMBL6226325 | 0.81 | MEN1 (0.51) | HDAC1HDAC8HDAC3HDAC2HDAC10 | |
| SCHEMBL5667857 | 0.80 | HDAC1 (0.46) | HDAC1HDAC8PIK3CAHDAC3HDAC2 | |
| SCHEMBL30628135 | 0.79 | PIK3CA (0.47) | HDAC1HDAC8PIK3CACNR2PSEN1 | |
| SCHEMBL6222420 | 0.79 | VNN1 (0.47) | HDAC1HDAC8PIK3CAHDAC3HDAC2 | |
| SCHEMBL6223798 | 0.77 | TDP1 (0.38) | RXRARXRBHRH3 | |
| SCHEMBL3893395 | 0.77 | L3MBTL1 (0.51) | HDAC1HDAC8HDAC3HDAC2HDAC10 | |
| SCHEMBL5509133 | 0.76 | HDAC1 (0.62) | HDAC1HDAC8SRD5A2CES2CES1 | |
| SCHEMBL7359518 | 0.76 | VNN1 (0.45) | HDAC1HDAC8HDAC3HDAC2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411942-A4 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMA CORP (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1411942-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | Synaptic Pharmaceutical Corporation (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003004027-A1 | SUBSTITUTED ANILINIC PIPERIDINES AS MCH SELECTIVE ANTAGONISTS | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2003-01-16 | — | — | WO | disclosed |